| Home Team | Score | | Score | Away Team |
| 05 October 2021 |
| Diamonds | 25 |
v
| 0 | Sheffield Hallam University 1 |
| Dronfield 3 | 40 |
v
| 15 | Dronfield 4 |
| Refreshers | 30 |
v
| 31 | University of Sheffield 7 |
| Sheffield Medics 2 | 26 |
v
| 10 | Sheffield Medics 3 |
| Sheffield Tigers Gold | 34 |
v
| 15 | University of Sheffield 8 |
| 12 October 2021 |
| Dronfield 3 | 60 |
v
| 9 | Refreshers |
| Sheffield Medics 2 | 22 |
v
| 20 | Dronfield 4 |
| Sheffield Medics 3 | 18 |
v
| 22 | Sheffield Hallam University 1 |
| 19 October 2021 |
| Dronfield 4 | 29 |
v
| 20 | University of Sheffield 7 |
| Sheffield Hallam University 1 | 16 |
v
| 37 | Sheffield Tigers Gold |
| Sheffield Medics 2 | 28 |
v
| 12 | Diamonds |
| Sheffield Medics 3 | 5 |
v
| 36 | Dronfield 3 |
| University of Sheffield 8 | 47 |
v
| 15 | Refreshers |
| 26 October 2021 |
| Dronfield 3 | 34 |
v
| 14 | University of Sheffield 7 |
| University of Sheffield 8 | 30 |
v
| 7 | Sheffield Medics 3 |
| 02 November 2021 |
| Dronfield 3 | 49 |
v
| 9 | Diamonds |
| Refreshers | 30 |
v
| 38 | Dronfield 4 |
| Sheffield Tigers Gold | 26 |
v
| 22 | Sheffield Medics 2 |
| University of Sheffield 7 | 23 |
v
| 20 | Sheffield Medics 3 |
| University of Sheffield 8 | 34 |
v
| 21 | Sheffield Hallam University 1 |
| 09 November 2021 |
| Diamonds | 10 |
v
| 43 | University of Sheffield 8 |
| Dronfield 4 | 32 |
v
| 16 | Sheffield Hallam University 1 |
| 16 November 2021 |
| Diamonds | 9 |
v
| 30 | University of Sheffield 7 |
| Dronfield 3 | 37 |
v
| 23 | Sheffield Tigers Gold |
| Sheffield Hallam University 1 | 25 |
v
| 18 | Refreshers |
| Sheffield Medics 2 | 14 |
v
| 30 | University of Sheffield 8 |
| Sheffield Medics 3 | 28 |
v
| 23 | Dronfield 4 |
| 30 November 2021 |
| Dronfield 4 | 24 |
v
| 35 | University of Sheffield 8 |
| Sheffield Hallam University 1 | 20 |
v
| 42 | University of Sheffield 7 |
| 07 December 2021 |
| Dronfield 4 | 45 |
v
| 13 | Diamonds |
| Refreshers | 13 |
v
| 21 | Sheffield Medics 3 |
| Sheffield Hallam University 1 | 19 |
v
| 25 | Sheffield Medics 2 |
| University of Sheffield 7 | 34 |
v
| 22 | Sheffield Tigers Gold |
| University of Sheffield 8 | 27 |
v
| 33 | Dronfield 3 |
| 11 January 2022 |
| Diamonds | 12 |
v
| 35 | Sheffield Medics 3 |
| Dronfield 3 | 25 |
v
| 0 | Sheffield Hallam University 1 |
| Sheffield Medics 2 | 38 |
v
| 21 | Refreshers |
| Sheffield Tigers Gold | 36 |
v
| 22 | Dronfield 4 |
| University of Sheffield 7 | |
v
| | University of Sheffield 8 |
| 25 January 2022 |
| Dronfield 4 | 22 |
v
| 24 | University of Sheffield 8 |
| Refreshers | 35 |
v
| 19 | Diamonds |
| Sheffield Hallam University 1 | 18 |
v
| 29 | University of Sheffield 7 |
| Sheffield Medics 2 | 19 |
v
| 41 | Dronfield 3 |
| Sheffield Medics 3 | 14 |
v
| 52 | Sheffield Tigers Gold |
| 01 February 2022 |
| Sheffield Medics 2 | 28 |
v
| 19 | Diamonds |
| 08 February 2022 |
| Dronfield 3 | 64 |
v
| 18 | Refreshers |
| Dronfield 4 | 33 |
v
| 18 | Sheffield Hallam University 1 |
| Sheffield Tigers Gold | 42 |
v
| 14 | Diamonds |
| University of Sheffield 7 | 21 |
v
| 29 | Sheffield Medics 2 |
| University of Sheffield 8 | 34 |
v
| 12 | Sheffield Medics 3 |
| 01 March 2022 |
| Dronfield 3 | 43 |
v
| 19 | University of Sheffield 7 |
| Refreshers | 17 |
v
| 48 | University of Sheffield 8 |
| Sheffield Medics 2 | 25 |
v
| 0 | Dronfield 4 |
| Sheffield Medics 3 | |
v
| | Sheffield Hallam University 1 |
| Sheffield Tigers Gold | 37 |
v
| 25 | Diamonds |
| 15 March 2022 |
| Diamonds | 15 |
v
| 23 | Sheffield Hallam University 1 |
| Dronfield 3 | 40 |
v
| 24 | Dronfield 4 |
| Refreshers | 14 |
v
| 52 | University of Sheffield 7 |
| Sheffield Medics 2 | 26 |
v
| 18 | Sheffield Medics 3 |
| Sheffield Tigers Gold | 24 |
v
| 34 | University of Sheffield 8 |
| 29 March 2022 |
| Diamonds | 12 |
v
| 46 | University of Sheffield 8 |
| Dronfield 4 | 18 |
v
| 41 | University of Sheffield 7 |
| Sheffield Hallam University 1 | 10 |
v
| 45 | Sheffield Tigers Gold |
| Sheffield Medics 2 | 27 |
v
| 17 | Refreshers |
| Sheffield Medics 3 | 16 |
v
| 53 | Dronfield 3 |
| 26 April 2022 |
| Sheffield Tigers Gold | 43 |
v
| 20 | Refreshers |
| 03 May 2022 |
| Dronfield 3 | 51 |
v
| 7 | Diamonds |
| Refreshers | 49 |
v
| 39 | Dronfield 4 |
| Sheffield Tigers Gold | 39 |
v
| 16 | Sheffield Medics 2 |
| University of Sheffield 7 | 14 |
v
| 13 | Sheffield Medics 3 |
| University of Sheffield 8 | 28 |
v
| 14 | Sheffield Hallam University 1 |
| 17 May 2022 |
| Diamonds | 17 |
v
| 35 | University of Sheffield 7 |
| Dronfield 3 | 30 |
v
| 15 | Sheffield Tigers Gold |
| Sheffield Hallam University 1 | 35 |
v
| 34 | Refreshers |
| Sheffield Medics 2 | 25 |
v
| 33 | University of Sheffield 8 |
| Sheffield Medics 3 | 18 |
v
| 37 | Dronfield 4 |
| 24 May 2022 |
| Refreshers | 20 |
v
| 49 | Sheffield Tigers Gold |
| Sheffield Medics 2 | 17 |
v
| 24 | University of Sheffield 7 |
| 31 May 2022 |
| Dronfield 4 | 33 |
v
| 26 | Diamonds |
| Refreshers | 31 |
v
| 26 | Sheffield Medics 3 |
| Sheffield Hallam University 1 | 0 |
v
| 25 | Sheffield Medics 2 |
| University of Sheffield 7 | 19 |
v
| 33 | Sheffield Tigers Gold |
| University of Sheffield 8 | 18 |
v
| 34 | Dronfield 3 |
| 07 June 2022 |
| Diamonds | 20 |
v
| 24 | Sheffield Medics 3 |
| Dronfield 3 | |
v
| | Sheffield Hallam University 1 |
| Sheffield Tigers Gold | 27 |
v
| 18 | Dronfield 4 |
| University of Sheffield 7 | 26 |
v
| 37 | University of Sheffield 8 |
| 14 June 2022 |
| Refreshers | 26 |
v
| 27 | Diamonds |
| Sheffield Medics 2 | 12 |
v
| 47 | Dronfield 3 |
| Sheffield Medics 3 | 11 |
v
| 36 | Sheffield Tigers Gold |