| Home Team | Score | | Score | Away Team |
| 05 October 2021 |
| Fizzio | 31 |
v
| 15 | Sheffield Stormers 3 |
| Sheffield Medics 1 | 29 |
v
| 40 | Sheffield Concord 3 |
| 12 October 2021 |
| Barnsley Aces 1 | 44 |
v
| 29 | Fizzio |
| Sheffield Concord 3 | 42 |
v
| 12 | Sheffield Stormers 3 |
| Sheffield Concord 4 | 29 |
v
| 40 | Sheffield Medics 1 |
| Sirens | 42 |
v
| 31 | Crystals |
| University of Sheffield 6 | 22 |
v
| 38 | Dronfield 2 |
| 19 October 2021 |
| Barnsley Aces 1 | 45 |
v
| 31 | University of Sheffield 6 |
| Crystals | 25 |
v
| 33 | Dronfield 2 |
| Sirens | 45 |
v
| 34 | Sheffield Concord 4 |
| 26 October 2021 |
| Crystals | 28 |
v
| 26 | Sheffield Medics 1 |
| Dronfield 2 | 43 |
v
| 54 | Barnsley Aces 1 |
| Fizzio | 32 |
v
| 27 | Sheffield Concord 4 |
| Sheffield Concord 3 | 20 |
v
| 37 | University of Sheffield 6 |
| Sheffield Stormers 3 | 20 |
v
| 54 | Sirens |
| 09 November 2021 |
| Barnsley Aces 1 | 53 |
v
| 30 | Sheffield Concord 3 |
| Fizzio | 24 |
v
| 37 | Dronfield 2 |
| Sheffield Concord 4 | 22 |
v
| 25 | Crystals |
| Sheffield Medics 1 | 40 |
v
| 24 | Sheffield Stormers 3 |
| Sirens | 32 |
v
| 22 | University of Sheffield 6 |
| 16 November 2021 |
| Crystals | 31 |
v
| 24 | Fizzio |
| Sheffield Concord 3 | 46 |
v
| 37 | Sirens |
| Sheffield Concord 4 | 21 |
v
| 26 | University of Sheffield 6 |
| 30 November 2021 |
| Dronfield 2 | 42 |
v
| 20 | Sheffield Concord 4 |
| Sheffield Concord 3 | 27 |
v
| 24 | Fizzio |
| Sheffield Stormers 3 | 10 |
v
| 43 | Crystals |
| Sirens | 38 |
v
| 45 | Barnsley Aces 1 |
| University of Sheffield 6 | 28 |
v
| 37 | Sheffield Medics 1 |
| 07 December 2021 |
| Dronfield 2 | |
v
| | Sheffield Medics 1 |
| Sheffield Stormers 3 | 0 |
v
| 25 | Barnsley Aces 1 |
| 14 December 2021 |
| Crystals | 25 |
v
| 0 | University of Sheffield 6 |
| Dronfield 2 | 35 |
v
| 22 | Sheffield Concord 3 |
| Fizzio | 25 |
v
| 0 | Sirens |
| Sheffield Concord 4 | 16 |
v
| 39 | Sheffield Stormers 3 |
| Sheffield Medics 1 | 0 |
v
| 25 | Barnsley Aces 1 |
| 18 January 2022 |
| Barnsley Aces 1 | 48 |
v
| 26 | Crystals |
| Sheffield Concord 3 | 28 |
v
| 34 | Sheffield Concord 4 |
| Sheffield Medics 1 | 45 |
v
| 30 | Fizzio |
| Sirens | 35 |
v
| 42 | Dronfield 2 |
| University of Sheffield 6 | 26 |
v
| 16 | Sheffield Stormers 3 |
| 01 February 2022 |
| Crystals | 35 |
v
| 23 | Fizzio |
| Dronfield 2 | |
v
| | Sheffield Medics 1 |
| Sheffield Concord 3 | 47 |
v
| 42 | Sirens |
| Sheffield Concord 4 | 26 |
v
| 24 | University of Sheffield 6 |
| Sheffield Stormers 3 | 68 |
v
| 13 | Barnsley Aces 1 |
| 08 February 2022 |
| Barnsley Aces 1 | 41 |
v
| 34 | Sheffield Concord 4 |
| 22 February 2022 |
| Barnsley Aces 1 | 41 |
v
| 21 | University of Sheffield 6 |
| Crystals | 17 |
v
| 40 | Dronfield 2 |
| Fizzio | 19 |
v
| 21 | Sheffield Stormers 3 |
| Sheffield Medics 1 | 12 |
v
| 32 | Sheffield Concord 3 |
| Sirens | 37 |
v
| 49 | Sheffield Concord 4 |
| 01 March 2022 |
| Sheffield Concord 3 | 36 |
v
| 18 | Crystals |
| Sirens | 46 |
v
| 33 | Sheffield Medics 1 |
| University of Sheffield 6 | 23 |
v
| 39 | Fizzio |
| 08 March 2022 |
| Sheffield Concord 3 | 38 |
v
| 33 | Crystals |
| Sheffield Concord 4 | 27 |
v
| 54 | Barnsley Aces 1 |
| Sheffield Stormers 3 | |
v
| | Dronfield 2 |
| Sirens | 44 |
v
| 36 | Sheffield Medics 1 |
| University of Sheffield 6 | 26 |
v
| 33 | Fizzio |
| 15 March 2022 |
| Sheffield Stormers 3 | 0 |
v
| 25 | Dronfield 2 |
| 22 March 2022 |
| Barnsley Aces 1 | 64 |
v
| 35 | Fizzio |
| Sheffield Concord 3 | 60 |
v
| 9 | Sheffield Stormers 3 |
| Sheffield Concord 4 | 35 |
v
| 36 | Sheffield Medics 1 |
| Sirens | 37 |
v
| 26 | Crystals |
| University of Sheffield 6 | 15 |
v
| 43 | Dronfield 2 |
| 26 April 2022 |
| Crystals | 25 |
v
| 27 | Sheffield Medics 1 |
| Dronfield 2 | 28 |
v
| 38 | Barnsley Aces 1 |
| Fizzio | 43 |
v
| 35 | Sheffield Concord 4 |
| Sheffield Concord 3 | 25 |
v
| 21 | University of Sheffield 6 |
| Sheffield Stormers 3 | 16 |
v
| 65 | Sirens |
| 10 May 2022 |
| Barnsley Aces 1 | 32 |
v
| 26 | Sheffield Concord 3 |
| Fizzio | 27 |
v
| 45 | Dronfield 2 |
| Sheffield Concord 4 | 33 |
v
| 36 | Crystals |
| Sheffield Medics 1 | 31 |
v
| 10 | Sheffield Stormers 3 |
| Sirens | 33 |
v
| 30 | University of Sheffield 6 |
| 24 May 2022 |
| Dronfield 2 | |
v
| | Sheffield Concord 4 |
| Sheffield Concord 3 | 32 |
v
| 24 | Fizzio |
| Sheffield Stormers 3 | 24 |
v
| 45 | Crystals |
| Sirens | 30 |
v
| 49 | Barnsley Aces 1 |
| University of Sheffield 6 | 18 |
v
| 28 | Sheffield Medics 1 |
| 07 June 2022 |
| Crystals | 29 |
v
| 28 | University of Sheffield 6 |
| Dronfield 2 | 33 |
v
| 38 | Sheffield Concord 3 |
| Fizzio | 39 |
v
| 39 | Sirens |
| Sheffield Concord 4 | 28 |
v
| 12 | Sheffield Stormers 3 |
| Sheffield Medics 1 | 26 |
v
| 53 | Barnsley Aces 1 |
| 14 June 2022 |
| Barnsley Aces 1 | 46 |
v
| 30 | Crystals |
| Sheffield Concord 3 | 43 |
v
| 29 | Sheffield Concord 4 |
| Sheffield Medics 1 | 0 |
v
| 25 | Fizzio |
| Sirens | |
v
| | Dronfield 2 |
| University of Sheffield 6 | 37 |
v
| 14 | Sheffield Stormers 3 |