| Home Team | Score | | Score | Away Team |
| 03 October 2021 |
| Bingham Comets | 19 |
v
| 50 | Northants Storm Purple |
| Charnwood Rutland | 33 |
v
| 37 | Brigg |
| Long Eaton | 9 |
v
| 44 | Lincoln City |
| Market Harborough Panthers | 34 |
v
| 35 | Nottm City Phoenix |
| 31 October 2021 |
| Brigg | 35 |
v
| 33 | Market Harborough Panthers |
| Charnwood Rutland | 55 |
v
| 14 | Bingham Comets |
| Northants Storm Purple | 38 |
v
| 44 | Lincoln City |
| Nottm City Phoenix | 43 |
v
| 10 | Long Eaton |
| 14 November 2021 |
| Lincoln City | 29 |
v
| 32 | Charnwood Rutland |
| Long Eaton | 17 |
v
| 55 | Northants Storm Purple |
| Market Harborough Panthers | |
v
| | Bingham Comets |
| Nottm City Phoenix | 37 |
v
| 27 | Brigg |
| 28 November 2021 |
| Bingham Comets | 30 |
v
| 45 | Nottm City Phoenix |
| Brigg | |
v
| | Long Eaton |
| Charnwood Rutland | 34 |
v
| 26 | Northants Storm Purple |
| Market Harborough Panthers | 33 |
v
| 45 | Lincoln City |
| 12 December 2021 |
| Brigg | 46 |
v
| 18 | Bingham Comets |
| Long Eaton | 14 |
v
| 32 | Charnwood Rutland |
| Northants Storm Purple | 39 |
v
| 32 | Market Harborough Panthers |
| Nottm City Phoenix | 28 |
v
| 25 | Lincoln City |
| 16 January 2022 |
| Bingham Comets | 21 |
v
| 29 | Long Eaton |
| Lincoln City | 39 |
v
| 29 | Brigg |
| Market Harborough Panthers | 26 |
v
| 39 | Charnwood Rutland |
| Nottm City Phoenix | 48 |
v
| 28 | Northants Storm Purple |
| 06 February 2022 |
| Bingham Comets | 27 |
v
| 49 | Lincoln City |
| Brigg | 45 |
v
| 34 | Northants Storm Purple |
| Charnwood Rutland | 30 |
v
| 34 | Nottm City Phoenix |
| Long Eaton | 33 |
v
| 31 | Market Harborough Panthers |