League Points Table
| Team Name | Played | Won | Drawn | Loss | Goals Scored | Goals Against | Goals Avg | Goals +/- | Points |
| Oldham | 20 | 18 | 1 | 1 | 1169 | 781 | 1.50 | 388 | 94 |
| Trafford | 20 | 18 | 0 | 2 | 1037 | 795 | 1.30 | 242 | 92 |
| Chester | 20 | 14 | 1 | 5 | 1069 | 859 | 1.24 | 210 | 79 |
| Blackpool | 20 | 14 | 0 | 6 | 1099 | 983 | 1.12 | 116 | 77 |
| Tameside | 20 | 10 | 0 | 10 | 949 | 982 | 0.97 | -33 | 60 |
| YWCA Bury | 20 | 10 | 0 | 10 | 1004 | 1049 | 0.96 | -45 | 60 |
| Ribble Valley | 20 | 6 | 1 | 13 | 808 | 854 | 0.95 | -46 | 51 |
| Warrington | 20 | 7 | 1 | 12 | 761 | 910 | 0.84 | -149 | 49 |
| Dominoes | 20 | 3 | 2 | 15 | 880 | 997 | 0.88 | -117 | 40 |
| Manchester Fury | 20 | 4 | 0 | 16 | 836 | 1076 | 0.78 | -240 | 35 |
| Capricorn | 20 | 2 | 2 | 16 | 875 | 1201 | 0.73 | -326 | 30 |
***Penalties Applied - Please see Results Table
| Home Team | Score | | Score | Away Team |
| 03 October 2021 |
| Blackpool | 51 |
v
| 47 | Dominoes |
| Chester | 46 |
v
| 30 | Ribble Valley |
| Tameside | 82 |
v
| 26 | Capricorn |
| Warrington | 32 |
v
| 42 | Trafford |
| YWCA Bury | 51 |
v
| 45 | Manchester Fury |
| 10 October 2021 |
| Capricorn | 42 |
v
| 62 | Oldham |
| Dominoes | 44 |
v
| 47 | YWCA Bury |
| Manchester Fury | 34 |
v
| 40 | Tameside |
| Ribble Valley | 35 |
v
| 43 | Blackpool |
| Trafford | 36 |
v
| 45 | Chester |
| 17 October 2021 |
| Blackpool | 44 |
v
| 46 | Trafford |
| Chester | 59 |
v
| 35 | Warrington |
| Oldham | 78 |
v
| 47 | Manchester Fury |
| Tameside | 44 |
v
| 56 | Dominoes |
| YWCA Bury | 48 |
v
| 46 | Ribble Valley |
| 24 October 2021 |
| Dominoes | 46 |
v
| 55 | Oldham |
| Manchester Fury | 56 |
v
| 36 | Capricorn |
| Ribble Valley | 28 |
v
| 37 | Tameside |
| Trafford | 60 |
v
| 53 | YWCA Bury |
| Warrington | 34 |
v
| 70 | Blackpool |
| 31 October 2021 |
| Blackpool | 57 |
v
| 50 | Chester |
| Capricorn | 54 |
v
| 54 | Dominoes |
| Oldham | 50 |
v
| 29 | Ribble Valley |
| Tameside | 37 |
v
| 47 | Trafford |
| YWCA Bury | 62 |
v
| 38 | Warrington |
| 07 November 2021 |
| Chester | 56 |
v
| 45 | YWCA Bury |
| Dominoes | 46 |
v
| 53 | Manchester Fury |
| Ribble Valley | 40 |
v
| 40 | Capricorn |
| Trafford | 54 |
v
| 44 | Oldham |
| Warrington | 50 |
v
| 45 | Tameside |
| 14 November 2021 |
| Capricorn | 34 |
v
| 70 | Trafford |
| Manchester Fury | 34 |
v
| 51 | Ribble Valley |
| Oldham | 51 |
v
| 36 | Warrington |
| Tameside | 33 |
v
| 59 | Chester |
| YWCA Bury | 54 |
v
| 50 | Blackpool |
| 21 November 2021 |
| Blackpool | 44 |
v
| 55 | Tameside |
| Chester | 52 |
v
| 52 | Oldham |
| Ribble Valley | 44 |
v
| 49 | Dominoes |
| Trafford | 49 |
v
| 44 | Manchester Fury |
| Warrington | 44 |
v
| 36 | Capricorn |
| 28 November 2021 |
| Capricorn | 46 |
v
| 62 | Chester |
| Dominoes | 42 |
v
| 57 | Trafford |
| Manchester Fury | 43 |
v
| 35 | Warrington |
| Oldham | 69 |
v
| 33 | Blackpool |
| Tameside | 60 |
v
| 55 | YWCA Bury |
| 05 December 2021 |
| Blackpool | 67 |
v
| 55 | Capricorn |
| Trafford | 40 |
v
| 37 | Ribble Valley |
| Warrington | 49 |
v
| 40 | Dominoes |
| YWCA Bury | 30 |
v
| 67 | Oldham |
| 12 December 2021 |
| Capricorn | 52 |
v
| 59 | YWCA Bury |
| Dominoes | 47 |
v
| 71 | Chester |
| Manchester Fury | 40 |
v
| 65 | Blackpool |
| Oldham | 66 |
v
| 33 | Tameside |
| Ribble Valley | 32 |
v
| 40 | Warrington |
| 09 January 2022 |
| Capricorn | 51 |
v
| 71 | Tameside |
| Dominoes | 42 |
v
| 50 | Blackpool |
| Manchester Fury | 47 |
v
| 52 | YWCA Bury |
| Ribble Valley | 43 |
v
| 40 | Chester |
| Trafford | 37 |
v
| 35 | Warrington |
| 16 January 2022 |
| Blackpool | 51 |
v
| 48 | Ribble Valley |
| Chester | 32 |
v
| 47 | Trafford |
| Oldham | 73 |
v
| 36 | Capricorn |
| Tameside | 41 |
v
| 51 | Manchester Fury |
| YWCA Bury | 63 |
v
| 48 | Dominoes |
| 23 January 2022 |
| Dominoes | 38 |
v
| 44 | Tameside |
| Manchester Fury | 43 |
v
| 53 | Oldham |
| Ribble Valley | 39 |
v
| 42 | YWCA Bury |
| Warrington | 31 |
v
| 52 | Chester |
| 30 January 2022 |
| Chester | 45 |
v
| 40 | Manchester Fury |
| 06 February 2022 |
| Capricorn | 56 |
v
| 52 | Manchester Fury |
| Oldham | 51 |
v
| 34 | Dominoes |
| Tameside | 47 |
v
| 45 | Ribble Valley |
| YWCA Bury | 44 |
v
| 59 | Trafford |
| 13 February 2022 |
| Chester | 57 |
v
| 67 | Blackpool |
| Dominoes | 41 |
v
| 44 | Capricorn |
| Ribble Valley | 35 |
v
| 61 | Oldham |
| Trafford | 50 |
v
| 43 | Tameside |
| Warrington | 40 |
v
| 34 | YWCA Bury |
| 20 February 2022 |
| Oldham | 46 |
v
| 37 | Trafford |
| Tameside | 49 |
v
| 44 | Warrington |
| YWCA Bury | 48 |
v
| 59 | Chester |
| 27 February 2022 |
| Blackpool | 70 |
v
| 55 | YWCA Bury |
| Chester | 67 |
v
| 39 | Tameside |
| Ribble Valley | 66 |
v
| 30 | Manchester Fury |
| Trafford | 66 |
v
| 38 | Capricorn |
| Warrington | 28 |
v
| 54 | Oldham |
| 06 March 2022 |
| Capricorn | 40 |
v
| 42 | Warrington |
| Dominoes | 33 |
v
| 36 | Ribble Valley |
| Oldham | 41 |
v
| 31 | Chester |
| Tameside | 48 |
v
| 62 | Blackpool |
| 13 March 2022 |
| Blackpool | 46 |
v
| 63 | Oldham |
| Chester | 69 |
v
| 50 | Capricorn |
| Trafford | 59 |
v
| 44 | Dominoes |
| Warrington | 59 |
v
| 33 | Manchester Fury |
| YWCA Bury | 49 |
v
| 51 | Tameside |
| 20 March 2022 |
| Capricorn | 53 |
v
| 68 | Blackpool |
| Dominoes | 37 |
v
| 37 | Warrington |
| Manchester Fury | 40 |
v
| 65 | Chester |
| Oldham | 73 |
v
| 39 | YWCA Bury |
| Ribble Valley | 40 |
v
| 55 | Trafford |
| 21 March 2022 |
| Blackpool | 59 |
v
| 25 | Warrington |
| 22 March 2022 |
| Manchester Fury | 36 |
v
| 60 | Dominoes |
| 27 March 2022 |
| Blackpool | 64 |
v
| 45 | Manchester Fury |
| Chester | 52 |
v
| 32 | Dominoes |
| Tameside | 50 |
v
| 60 | Oldham |
| Warrington | 27 |
v
| 35 | Ribble Valley |
| YWCA Bury | 74 |
v
| 45 | Capricorn |
| 02 April 2022 |
| Capricorn | 41 |
v
| 49 | Ribble Valley |
| 03 April 2022 |
| Trafford | 62 |
v
| 38 | Blackpool |
| 07 April 2022 |
| Manchester Fury | 23 |
v
| 64 | Trafford |
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